Azo compounds useful for the treatment of cancer

摘要

Azo pyridine derivatives of formula (I) may be useful for the treatment of cancer. R1 is C1-6 alkyl, CF3, phenyl or 2-thienyl; R2 is C1-6 alkyl, phenyl or CF3; R3 R5 are H, C1-6 alkyl, halo, NO2, NH2 or haloalkyl; R6 is H, -(CH2)nC(O)OR7 or C(O)C6H4-R7; R7 is C1-6 alkyl or phenyl optionally substituted by 1-3 substituents selected from CF3, NO2 and halo; n is 0-6. The compound may be 3-Cyano-4,6-dimethyl-5-(2′-flurophenylazo)-pyridine-2(1H)-one, 3-Cyano-4,6-dimethyl-5-(3′-trifluromethylphenylazo)-pyridine-2(1H)-one or 3-Cyano-4-methyl-6-phenyl-5-(4′-flurophenylazo)-pyridine-2(1H)-one. The compounds may be especially useful for the treatment of breast cancer and colorectal cancer.