发明名称 |
SELF-REPLICATING RNA PRIME - PROTEIN BOOST VACCINES |
摘要 |
This invention generally relates to immunogenic compositions that comprise an RNA component and a polypeptide component. Immunogenic compositions that deliver antigenic epitopes in two different forms—a first epitope from a pathogen, in RNA-coded form; and a second epitope from the same pathogen, in polypeptide form—are effective in inducing immune response to the pathogen. The invention also relates to a kit comprising an RNA-based priming composition and a polypeptide-based boosting composition. The kit may be used for sequential administration of the priming and the boosting compositions. |
申请公布号 |
EP2729168(A2) |
申请公布日期 |
2014.05.14 |
申请号 |
EP20120735421 |
申请日期 |
2012.07.06 |
申请人 |
NOVARTIS AG |
发明人 |
GEALL, ANDREW;BARNETT, SUSAN;OTTEN, GILLIS |
分类号 |
A61K39/12;A61K39/295;A61P11/00;A61P31/00 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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