TRANSDUCIBLE DELIVERY OF NUCLEIC ACIDS BY REVERSIBLE PHOSPHOTRIESTER CHARGE NEUTRALIZATION PROTECTING GROUPS
摘要
This disclosure relates to nucleic acid constructs modified to have a reduced net anionic charge. In some aspects the constructs comprise phosphodiester and/or phosphothioate protecting groups. The disclosure also provide methods of making and using such constructs.
申请公布号
EP2046964(A4)
申请公布日期
2014.05.14
申请号
EP20070796847
申请日期
2007.07.11
申请人
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人
DOWDY, STEVEN, F.;PETERSEN, SCOTT, G.;MEADE, BRYAN, R.