BIOACTIVE SURFACE CAPABLE OF GENETICALLY MODIFYING BIOLOGICAL CELLS OR TISSUES AND USE THEREOF

摘要

The invention relates to a bioactive surface comprising a polymer matrix, a connecting complex comprising at least one compound covalently bound to the surface of the polymer matrix, and a gene transfer vector bound to the connecting complex, where the compound of complex is covalently bound to the transfer vector using a group selected from among carboxyl, amino, isocyanate and hydroxyl, and to the use of the bioactive surface for transferring a nucleic acid to a cell. The invention also relates to an implantable device characterized in that at least part of the surface thereof is coated with said bioactive surface, and to the use of the implantable device for transferring a nucleic acid to a cell. In addition, the invention relates to a method for transferring a nucleic acid to a cell and to a kit for carrying out said method.