发明名称 |
MODULATION OF COMPLEMENT-DEPENDENT CYTOTOXICITY THROUGH MODIFICATIONS OF THE C-TERMINUS OF ANTIBODY HEAVY CHAINS |
摘要 |
Antibody variants having decreased or increased ability to mediate CDC due to modifications at the C-terminus of their heavy chains are described. Methods of generating such antibodies, as well as nucleotide constructs and host cells suitable for the production of said antibodies are also described. |
申请公布号 |
EP2729496(A1) |
申请公布日期 |
2014.05.14 |
申请号 |
EP20120731507 |
申请日期 |
2012.07.06 |
申请人 |
GENMAB A/S |
发明人 |
PARREN, PAUL;VAN BERKEL, PATRICK;VAN DEN BREMER, EWALD |
分类号 |
C07K16/00 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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