发明名称 |
Dosage form with impeded abuse |
摘要 |
A multiparticulate dosage form formulated to make misuse more difficult containing least one active substance with potential for misuse (A), at least one synthetic or natural polymer (C), optionally at least one natural, semi-synthetic or synthetic wax (D), at least one disintegrant (E) and optionally one or more additional physiologically compatible excipients (B), wherein the individual particles of the dosage form display a breaking strength of at least 500 N and a release of active substance of at least 75% after 45 minutes measured according to Ph.Eur. in the paddle mixer with sinker in 600 ml of aqueous buffer solution with a pH value of 1.2 at 37° C. and 75 rpm. |
申请公布号 |
US8722086(B2) |
申请公布日期 |
2014.05.13 |
申请号 |
US20080044586 |
申请日期 |
2008.03.07 |
申请人 |
ARKENAU-MARIĆ ELISABETH;BARTHOLOMAEUS JOHANNES;ZIEGLER IRIS;HAUPTS MARCEL;GRUENENTHAL GMBH |
发明人 |
ARKENAU-MARIĆ ELISABETH;BARTHOLOMAEUS JOHANNES;ZIEGLER IRIS;HAUPTS MARCEL |
分类号 |
A61K9/20;A61K9/16;A61K9/50 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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