发明名称 |
Extended-release minocycline dosage forms |
摘要 |
An oral dosage form has the following: an amount of minocycline selected from the group consisting of 55 mg, 80 mg, and 105 mg; an amount of lactose monohydrate; an amount of hydroxypropylmethylcellulose. The hydroxypropylmethylcellulose is at least 8.3 to about 9.8% hydroxypropoxylated. The minocycline in the oral dosage form has a dissolution profile or release rates about 35% to about 50% in 1 hour, about 60% to about 75% in 2 hours, and at least about 90% in 4 hours. There is also provided a method of treating acne in a human and a method of assisting a physician in prescribing a dose of minocycline for the treatment of acne. |
申请公布号 |
US8722650(B1) |
申请公布日期 |
2014.05.13 |
申请号 |
US20100861424 |
申请日期 |
2010.08.23 |
申请人 |
WORTZMAN MITCHELL;PLOTT R. TODD;NEWHARD STEVEN B.;WATT DAVID;MEDICIS PHARMACEUTICAL CORPORATION |
发明人 |
WORTZMAN MITCHELL;PLOTT R. TODD;NEWHARD STEVEN B.;WATT DAVID |
分类号 |
A61K9/16;A61K9/50;A61K9/52;A61K9/54;A61K31/65 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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