发明名称 |
T-cell receptor capable of recognising an antigen from cytomegalovirus |
摘要 |
The present invention provides a T-cell receptor (TCR) which binds to a peptide from the cytomegalovirus (CMV) phosphoprotein pp65 having the amino acid sequence NLVPMVATV (SEQ ID No. 1) when presented by a major histocompatability complex (MHC) molecule. The present invention also provides a nucleotide sequence encoding such a TCR, a vector comprising such a nucleotide sequence and its use to produce a CMV-specific T-cell. The present invention also provides the use of CMV-specific T-cell for cellular immunotherapy. |
申请公布号 |
US8722048(B2) |
申请公布日期 |
2014.05.13 |
申请号 |
US201013498564 |
申请日期 |
2010.09.29 |
申请人 |
STAUSS HANS;XUE SHAO-AN;UCL BUSINESS PLC |
发明人 |
STAUSS HANS;XUE SHAO-AN |
分类号 |
A61K39/42;C07K14/045;C07K14/725 |
主分类号 |
A61K39/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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