发明名称 |
Methods for the total chemical synthesis of enantiomerically-pure 7-(2′-trimethylsilyl)ethyl camptothecin |
摘要 |
The present invention discloses and claims five (5) novel, highly efficient synthetic routes for the total synthesis of enantiomerically-pure (i.e., 99%) 7-(2′-trimethylsilyl)ethyl camptothecin (BNP1350; Karenitecin; Cositecan). These aforementioned synthetic schemes are the first to disclose the total syntheses of 7-(2′-trimethylsilyl)ethyl camptothecin using a highly novel direct, non-linear and convergent synthetic strategy which involves annealing the key C7-(trimethylsilyl)ethyl side chain-bearing A ring key synthons to an enantiomerically-pure tricyclic pyridone; rather than through the conventional methodology which incorporates the C7-(trimethylsilyl)ethyl side chain as the final synthetic step on a totally synthesized camptothecin parent compound. The current novel synthetic approaches reported herein since utilize desirably functionalized A-ring with preinstalled trimethyl silyl ethyl side chain, the aforementioned synthetic methodologies have a wider scope of making wide range of pharmaceutically relevant A-ring substituted BNP1350 analogs by substituting desirably functionalized nitro or protected amino phenyl carboxy A-ring as the starting material. |
申请公布号 |
US8722886(B1) |
申请公布日期 |
2014.05.13 |
申请号 |
US201213694255 |
申请日期 |
2012.11.13 |
申请人 |
CHEN XINGHAI;HAUSHEER FREDERICK H.;MALAKHOV ANDREY;KOCHAT HARRY;BIONUMERIK PHARMACEUTICALS, INC. |
发明人 |
CHEN XINGHAI;HAUSHEER FREDERICK H.;MALAKHOV ANDREY;KOCHAT HARRY |
分类号 |
C07F7/02;C07D491/147 |
主分类号 |
C07F7/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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