发明名称 |
Human tissue factor antibody and uses thereof |
摘要 |
The invention relates to a humanized form of an antibody capable of preventing tissue factor (coagulation factor F3) signaling but which does not interfere with Factor VII binding or FX binding to tissue factor and does not prolong coagulation time. The antibody of the invention is useful in treating conditions, such as tumor progression, in which the associated cells express tissue factor and tissue factor signaling occurs. |
申请公布号 |
US8722044(B2) |
申请公布日期 |
2014.05.13 |
申请号 |
US201213398881 |
申请日期 |
2012.02.17 |
申请人 |
ALMAGRO JUAN CARLOS;ANDERSON GLENN MARK;CHI ELLEN;MARTINEZ CHRISTIAN;RAGHUNATHAN GOPALAN;SWANSON RONALD;TEPLYAKOV ALEXEY;TSE KAM-FAI;WU SHENG-JIUN;ZHOU HONG MIMI;JANSSEN BIOTECH, INC. |
发明人 |
ALMAGRO JUAN CARLOS;ANDERSON GLENN MARK;CHI ELLEN;MARTINEZ CHRISTIAN;RAGHUNATHAN GOPALAN;SWANSON RONALD;TEPLYAKOV ALEXEY;TSE KAM-FAI;WU SHENG-JIUN;ZHOU HONG MIMI |
分类号 |
A61K39/395;A61K39/00;C07K16/28;C07K16/36 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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