CRYSTAL STRUCTURE AND PEPTIDE INHIBITORS OF HAUSP DEUBIQUITINASE

摘要

Two vIRF4 (Kaposi′s sarcoma-related herpesvirus vIPvF4) peptides, vif1 corresponding to aa202-216 of vIRF4, and vif2 corresponding to aa220-236 of vIRF4 are a strong and selective HAUSP antagonist. The vif1 and vif2 peptides strongly suppress the activation of HAUSP DUB enzyme to ultimately induce the activation of p53 medium anticancer. The vif1 and vif2 peptides are useful for treating cancer with homogeny through the control of p53 activation in cancer cells. A crystal structure of a vIRF4-HAUSP TRAF domain complex is described. The structure interacts with HAUSP and suppresses the same to be useful for the design of computer support medicine causing a p53 medium cell cycle stop of the cancer cells.