发明名称 |
Methods and compositions for synthesis of long chain polyunsaturated fatty acids |
摘要 |
The present invention relates to fatty acid desaturases able to catalyze the conversion of oleic acid to linoleic acid, linoleic acid toγ-linolenic acid, or of alpha-linolenic acid to stearidonic acid. Nucleic acid sequences encoding desaturases, nucleic acid sequences which hybridize thereto, DNA constructs comprising a desaturase gene, and recombinant host microorganism or animal expressing increased levels of a desaturase are described. Methods for desaturating a fatty acid and for producing a desaturated fatty acid by expressing increased levels of a desaturase are disclosed. Fatty acids, and oils containing them, which have been desaturated by a desaturase produced by recombinant host microorganisms or animals are provided. Pharmaceutical compositions, infant formulas or dietary supplements containing fatty acids which have been desaturated by a desaturase produced by a recombinant host microorganism or animal also are described. |
申请公布号 |
US8722384(B2) |
申请公布日期 |
2014.05.13 |
申请号 |
US20090414274 |
申请日期 |
2009.03.30 |
申请人 |
KNUTZON DEBORAH;MUKERJI PRADIP;HUANG YUNG-SHENG;THURMOND JENNIFER;CHAUDHARY SUNITA;LEONARD AMANDA EUN-YEONG;CALGENE LLC;ABBOTT LABORATORIES |
发明人 |
KNUTZON DEBORAH;MUKERJI PRADIP;HUANG YUNG-SHENG;THURMOND JENNIFER;CHAUDHARY SUNITA;LEONARD AMANDA EUN-YEONG |
分类号 |
C12N1/20;A23D9/00;A23K1/16;A23L1/28;A23L1/29;A23L1/30;A61K8/30;A61K8/36;A61K8/99;A61K31/202;A61K31/232;A61K38/00;A61P17/00;C07H21/04;C11B1/00;C12N1/19;C12N5/10;C12N9/02;C12N15/09;C12N15/53;C12N15/81;C12N15/82;C12P7/64 |
主分类号 |
C12N1/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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