发明名称 |
Genetically engineered or transgenic rats exhibiting a cancer phenotype due to a disruption of germline tumor suppressor genes |
摘要 |
This invention relates to the engineering of animal cells, preferably mammalian, more preferably rat, that are deficient due to the disruption of tumor suppressor gene(s) or gene product(s). In another aspect, the invention relates to genetically modified rats, as well as the descendants and ancestors of such animals, which are animal models of human cancer and methods of their use. |
申请公布号 |
US8722964(B2) |
申请公布日期 |
2014.05.13 |
申请号 |
US20100766284 |
申请日期 |
2010.04.23 |
申请人 |
OSTERTAG ERIC M.;CRAWFORD JOHN STUART;TRANSPOSAGEN BIOPHARMACEUTICALS, INC. |
发明人 |
OSTERTAG ERIC M.;CRAWFORD JOHN STUART |
分类号 |
C12N15/00;A01K67/027;C12N15/85 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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