发明名称 |
Benzazepinderivater til anvendelse som vasopressinantagonister |
摘要 |
<p>The present invention provides a benzazepine compound that can maintain for a long period of time the blood level of tolvaptan enabling to provide the desired pharmaceutical effects. The benzazepine compound of the present invention is represented by general formula (1) wherein R 1 represents a -CO-(CH 2 ) n -COR 2 group (wherein n is an integer of 1 to 4, and R 2 is (2-1) a hydroxy group; (2-2) a lower alkoxy group optionally substituted with a hydroxy group, a lower alkanoyl group, a lower alkanoyloxy group, a lower alkoxycarbonyloxy group, a cycloalkyloxycarbonyloxy group, or 5-methyl-2-oxo-1,3-dioxol-4-yl; or (2-3) an amino group optionally substituted with a hydroxy-lower alkyl group), or the like.</p> |
申请公布号 |
DK2374797(T3) |
申请公布日期 |
2014.05.12 |
申请号 |
DK20110172828T |
申请日期 |
2008.06.26 |
申请人 |
OTSUKA PHARMACEUTICAL CO., LTD. |
发明人 |
MATSUDA, TAKAKUNI;YAMADA, KEIGO;KATO, YUSUKE;KONDO, KAZUMI;MENJO, YASUHIRO;TOMOYASU, TAKAHIRO;MIYAMURA, SHIN;TOMOHIRA, YUSO |
分类号 |
C07D223/16;A61K31/55;A61P7/00;A61P9/00;C07D405/12 |
主分类号 |
C07D223/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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