| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to method of degarelix obtaining. Claimed is stage-by-stage synthesis of degarelix, containing 0.3 wt % or less than analogue 4-([2-(5-gidantoyl)]acetylamino)-phenylalanine, on solid amino group-containing substrate, which includes the following stages: supply of amino acid or peptide solution, where ?-aminogroup is protected by fluorenylmethyloxycarbonyl group (Fmoc); bringing substrate in contact with said solution in presence of reagent to create peptide bond between carboxyl group of amino acid or peptide and solid amino group-containing substrate, connected with said substrate; removal of Fmoc by bringing substrate in contact with organic base, in particular piperidine, in organic solvent.EFFECT: increase of method efficiency.10 cl, 4 ex |
