| 发明名称 |
GLYCOSIDASE INHIBITORS AND USES THEREOF |
| 摘要 |
The invention provides compounds with enhanced permeability for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulatio or deficiency of O-GlcNAc. |
| 申请公布号 |
CA2890115(A1) |
申请公布日期 |
2014.05.08 |
| 申请号 |
CA20132890115 |
申请日期 |
2013.10.30 |
| 申请人 |
ALECTOS THERAPEUTICS INC.;MERCK SHARP & DOHME CORP. |
发明人 |
KAUL, RAMESH;MCEACHERN, ERNEST J.;VOCADLO, DAVID J.;ZHOU, YUANXI;DANG, QUN;SELNICK, HAROLD G. |
| 分类号 |
C07D513/04;A61K31/424;A61K31/7056;A61P3/00;C07D498/04;C07H9/06 |
主分类号 |
C07D513/04 |
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