HUMAN INVASION SIGNATURE FOR PROGNOSIS OF METASTATIC RISK

摘要

Methods and products are provided for determining if a subject having a tumor is (i) at risk of metastasis of the tumor, or (ii) at risk of recurrence of the tumor after treatment of the tumor. Methods of treatment of cancer, tumors and metastasis are also provided. Also provided is n method of determining a subject having a tumor as (i) at risk of metastasis of the tumor, (ii) at risk of invasion of the tumor, or (iii) at risk of recurrence of the tumor after treatment of the tumor, comprising obtaining a sample of the tumor and determining the level of expression in the sample of one or more of the genes (I) in the upregulated DNA Replication and Repair section of Table 1; (2) in the upregulated Embryonic and Tissue Development section of Table I; (3) in the upregulated Cellular Movement and Development section of Table I; (4) in the upregulated Cell-to-Cell Signaling and interaction section of Table I; and/or (5) in the upregulated Cellular Assembly and Organization section of Table I.