NEURAL STEM CELL HAVING INCREASED PASSAGE ABILITY, METHOD FOR PRODUCING SAID NEURAL STEM CELL HAVING INCREASED PASSAGE ABILITY, AND METHOD FOR CULTURING NEURAL STEM CELL FOR INCREASING PASSAGE ABILITY OF SAID NEURAL STEM CELL

摘要

The present invention addresses the problem of providing: a neural stem cell having an increased passage ability; a method for producing the neural stem cell having an increased passage ability; and other. In one embodiment, the present invention provides a neural stem cell having an increased passage ability, said neural stem cell having the following characteristic properties: (a) a N-type calcium channel gene is knocked out or knocked down in the cell; (b) the inflow of Ca2+ through a N-type calcium channel is substantially eliminated or reduced in the cell; (c) the cell can be subcultured for at least 4 generations (preferably 15 generations); and (d) the cell can maintain an ability of being differentiated into a nerve cell even after the cell is subcultured for 4 generations (preferably 15 generations).