| 摘要 |
<p>Disclosed is a tapentadol hydrochloride crystalline form C having high stability and having characteristic peaks at 14.627 (100%), 15.476 (20.7%), 16.710 (33.7%), 18.999 (48.3%), 20.479 (80.7%), 21.790 (27.9%), 25.110 (35.2%), 25.911 (36.4%), 26.292 (58.5%), 27.385 (32.8%) and 27.77 (37.5%) represented by diffraction angle 2θ, as shown in a powder X-ray diffraction pattern; also provided are a preparation method and use of the crystalline form; preparation of the tapentadol hydrochloride crystalline form by using the method is characterized by high repeatability and strong operability. The tapentadol hydrochloride may be used to prepare a pharmaceutical composition, and has important significance for use in preparation of drugs for treating pains or urinary incontinence.</p> |
