THROMBOPOIETIN MIMETICS FOR THE TREATMENT OF RADIATION OR CHEMICAL INDUCED BONE MARROW INJURY
摘要
Disclosed are transgenic non-human mammals, which useful for the screening of thrombopoietin mimetics, thrombopoietin receptor agonists, or thrombopoietin receptor antagonists active on the human thrombopoietin receptor. The transgenic non-human mammal has a genome that comprises a stably integrated transgene construct comprising a polynucleotide sequence encoding a humanized thrombopoietin receptor wherein said transgenic non-human mammal has a baseline blood platelet count corresponding to a physiological blood platelet count of a matched non-transgenic non- human mammal. The chimeric thrombopoietin receptor comprises either the transmembrane domain of a human thrombopoietin receptor or both the extracellular and transmembrane domains of a human thrombopoietin receptor operably coupled to a cytoplasmic domain of a non-human thrombopoietin receptor.
申请公布号
WO2014028509(A3)
申请公布日期
2014.05.08
申请号
WO2013US54758
申请日期
2013.08.13
申请人
UNIVERSITY OF ROCHESTER;CHEN, YUHCHYAU;WU, J.,H., DAVID;LIESVELD, JANE, L.;GAN, LIN
发明人
CHEN, YUHCHYAU;WU, J.,H., DAVID;LIESVELD, JANE, L.;GAN, LIN