<p>The present invention provides compounds comprising oligonucleotides complementary to a pyruvate kinase M transcript. Certain such compounds are useful for hybridizing to a pyruvate kinase M transcript, including but not limited to a pyruvate kinase M transcript in a cell. In certain embodiments, such hybridization results in modulation of splicing of the pyruvate kinase M transcript. In certain embodiments, such compounds are used to treat one or more symptoms associated with cancer.</p>
申请公布号
WO2014071078(A1)
申请公布日期
2014.05.08
申请号
WO2013US67881
申请日期
2013.10.31
申请人
ISIS PHARMACEUTICALS, INC.;COLD SPRING HARBOR LABORATORY