(1R,6S)-2-AZABICYCLO[4.3.0] NONANE-8,8-DIPHOSPHONIC ACID AND ITS USE IN TREATING OR PREVENTING BONE DISORDERS, FOR EXAMPLE, OSTEOPOROSIS OR PAGET'S DISEASE

摘要

Disclosed is a new composition of matter, substantially enantiomerically pure (1R,6S)-2-Azabicyclo-[4.3.0]nonane-8,8-diphosphonic acid, methods of preparing this new composition of matter, a pharmaceutical composition comprising the new composition, and administration of the composition in methods of treating bone disorders such as osteoporosis, osteolytic bone metastasis, rheumatoid arthritis and osteoarthritis.