发明名称 |
Neuroprotective multi-target directed drugs |
摘要 |
<p>A new family of multitarget molecules able to interact with acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), as well as with monoamino oxidase (MAO) A and B, has been synthesized. Novel compounds have been designed using a conjunctive approach that combines the benzylpiperidine moiety of the AChE inhibitor donepezil, connected through an oligomethylene linker, to a central nitrogen atom substituted with the propargyl moiety responsible for the MAO inhibition, and a 8-hydroxy-5-methylaminoquinoline functional group, the biometal pro-chelator motif. Overall, the results suggest that the new compounds are promising multitarget drug candidates with potencial impact for AD therapy.</p> |
申请公布号 |
EP2727916(A1) |
申请公布日期 |
2014.05.07 |
申请号 |
EP20120190483 |
申请日期 |
2012.10.30 |
申请人 |
UNIVERSITAT AUTONOMA DE BARCELONA;CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC);NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY;UNIVERSIDAD DE ALCALA |
发明人 |
ESTEBAN, GERARD;UNZETA, MERCEDES;INOKUCHI, TSUTOMU;MARCO-CONTELLES, JOSE LUIS;SAMADI, ABDELOUAHID;IRIEPA, ISABEL;OJIMA, MASAKI;LI, WANG |
分类号 |
C07D401/12;A61K31/4545;A61P25/28 |
主分类号 |
C07D401/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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