| 摘要 |
The present invention provides compounds of the formula (I) wherein: X1, X2 and X3 are heteroatoms; R4, R5, R6, R7, R8, R9 and R10 are independently selected from H, halo,—OH,—NO2,—CN and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; and Z is optionally substituted C1-8 straight-chained or branched aliphatic, optionally containing 1 or more double or triple bonds, wherein one or more carbons are optionally replaced by R* wherein R* is optionally substituted cycloalkyl, heterocycloalkyl, aryl or heteroaryl; an amino acid residue, H,—CN,—C(O)—,—C(O)C(O)—,—C(O)NR1—,—C(O)NR1NR2—,—C(O)O—,—OC(O)—,—NR1CO2—,—O—,—NR1C(O)NR2—,—OC(O)NR1—,—NR1NR2—,—NR1C(O)—,—S—,—SO—,—SO2—,—NR1—,—SO2NR1—,—NR1R2, or—NR1SO2—, wherein R1 and R2 are independently selected from H and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; or where R* is NR1R2, R1 and R2 optionally together with the nitrogen atom form an optionally substituted 5-12 membered ring, said ring optionally comprising 1 or more heteroatoms or a group selected from—CO—,—SO—,—SO2—and—PO—; or a pharmaceutically acceptable salt, ester or prodrug thereof. |
