发明名称 |
Antibodies against human IL-12 |
摘要 |
The present invention relates to novel p75 heterodimer specific anti-human IL-12 antibodies that are characterized by a higher potency and greater efficacy in neutralizing human IL-12 bioactivity than known heterodimer specific IL-12 monoclonal antibodies. The heterodimer specific antibodies recognize one or more epitopes of the human IL-12 p75 heterodimer, but do not bind to the p40 subunit alone. The heterodimer specific IL-12 antibodies neutralize rhesus monkey IL-12 bioactivity with a potency similar to their potency for neutralizing human IL-12 bioactivity making them useful IL-12 antagonists for in vivo studies in the rhesus monkey. |
申请公布号 |
US8716449(B2) |
申请公布日期 |
2014.05.06 |
申请号 |
US20050185615 |
申请日期 |
2005.07.19 |
申请人 |
GATELY MAURICE KENT;PRESKY DAVID HOWARD;HOFFMAN-LAROCHE, INC. |
发明人 |
GATELY MAURICE KENT;PRESKY DAVID HOWARD |
分类号 |
C07K16/00;C07K1/00;C07K16/24;C12P21/08 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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