发明名称 |
COMPOUNDS WITH MEDICINAL EFFECTS DUE TO INTERACTION WITH THE GLUCOCORTICOID RECEPTOR |
摘要 |
The invention provides for compounds having the structure according to the formula I wherein: X is a carbon or nitrogen atom; Ar is phenyl or heteroaromatic ring; R1 is hydrogen, halogen, CN or (1 C-4C)alkyl; R2 is hydrogen, halogen or optionally fluorinated (1 C-3C)alkoxy; R3 and R5 are independently hydrogen, optionally halogenated (1C- 4C)alkyl, optionally halogenated (1 C-4C)alkoxy, optionally halogenated aryl(1C-4C)alkoxy, optionally halogenated (1 C-4C)alkenyl or hydroxylmethyl; R4 is hydrogen, halogen, optionally halogenated (1 C-4C)alkoxy or optionally halogenated aryl(1 C-4C)alkoxy; R6 is hydrogen, benzyl, optionally substituted with one or more halogens or (1 C-4C)alkyl, or R6 is optionally halogenated (1 C-4C)alkyl; each R7 independently is hydrogen, halogen, optionally halogenated (1 C-4C)alkyl or optionally halogenated (1 C-4C)alkoxy and pharmaceutically suitable acid addition salts thereof for use as glucocorticoid receptor modulators, in particular for treatment of central nervous system disorders. |
申请公布号 |
CA2631816(C) |
申请公布日期 |
2014.05.06 |
申请号 |
CA20062631816 |
申请日期 |
2006.12.18 |
申请人 |
N.V. ORGANON;PHARMACOPEIA, INC. |
发明人 |
HAMILTON, NIALL MORTON;GROVE, SIMON JAMES ANTHONY;KICZUN, MICHAEL JOHN;MORPHY, JOHN RICHARD;SHERBORNE, BRAD;LITTLEWOOD, PETER THOMAS ALBERT;BROWN, ANGUS RICHARD;KINGSBURY, CELIA;OHLMEYER, MICHAEL;HO, KOC-KAN;KULTGEN, STEVEN G. |
分类号 |
C07C311/17;A61K31/18;A61K31/341;A61K31/415;A61K31/42;A61K31/44;A61K31/4436;A61K31/4439;A61P25/22;A61P25/24;C07D213/85;C07D231/18;C07D261/10;C07D307/64;C07D333/34;C07D401/12;C07D409/12;C07D413/12 |
主分类号 |
C07C311/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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