Disclosed is a new type of immunostimulating agent comprising an immunostimulating oligonucleotide complexed with a carrier which is safe and has a high transfection effect. The carrier complexed with the immunostimulating oligonucleotide to form the immunostimulating agent is a polysaccharide having .beta.-1,3-bonds (preferably .beta.-1,3-glucan such as schizophyllan). A preferred example of the immunostimulating oligonucleotide is one containing an unmethylated CpG motif. The polysaccharide for use is preferably modified with nucleic acid-binding functional group and/or cell membrane-affinitive functional group.
申请公布号
CA2527756(C)
申请公布日期
2014.05.06
申请号
CA20042527756
申请日期
2004.05.13
申请人
JAPAN SCIENCE AND TECHNOLOGY AGENCY;MITSUI SUGAR CO., LTD.