NON-POLYMERIC HEMATOPOIETIC CELL CLOTS FOR DELIVERY OF ACTIVE AGENTS

摘要

The invention encompasses a method of and apparatus for delivering a substance. The delivery of a substance entails administering to a subject a non polymeric hematopoeitic cell clot having a substance incorporated therein. The non polymeric hematopoeitic cell clot functions as the delivery vehicle for the substance. Specifically, the invention relates to a substance delivery system comprising: a bone marrow cell clot having a substance incorporated therein, wherein the substance comprises a gene delivery vehicle, proteins, bioactive molecules, or genetically engineered cells and wherein a polymer matrix is not incorporated into the clot or used as the structure for the clot having a substance incorporated therein. The invention also relates to methods and uses thereof for delivering a substance to a subject.