| 发明名称 |
FUNCTIONALIZED 1,2,4,5-TETRAZINE COMPOUNDS FOR USE IN BIOORTHOGONAL COUPLING REACTIONS |
| 摘要 |
<p>The present application relates to functionalized 1,2,4,5-tetrazine compounds. The compounds are useful in compositions and methods using bioorthogonal inverse electron demand Diels-Alder cycloaddition reactions for the rapid and specific covalent delivery of a "payload" to a ligand bound to a biological target.</p> |
| 申请公布号 |
WO2014065860(A1) |
申请公布日期 |
2014.05.01 |
| 申请号 |
WO2013US31524 |
申请日期 |
2013.03.14 |
| 申请人 |
THE GENERAL HOSPITAL CORPORATION;DEVARAJ, NEAL K.;KARVER, MARK R. |
发明人 |
DEVARAJ, NEAL K.;KARVER, MARK R.;HILDERBRAND, SCOTT A.;WEISSLEDER, RALPH |
| 分类号 |
C07D257/08;A61K31/4015;A61K31/44;C07D401/04;C07D403/04;C07D403/12 |
主分类号 |
C07D257/08 |
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