BI-SPECIFIC AFFINITY REAGENTS FOR CELL-LINEAGE-SPECIFIC TNF-ALPHA NEUTRALISATION

摘要

The invention relates to isolated bispecific affinity reagents, such as antibodies or antibody fragments that bind TNFα and a marker molecule for macrophages and/or neutrophils. The affinity reagents of the invention enable pathogenic sub-populations of TNFα to be neutralised, whilst protective sub-populations of TNFα are not affected.