TARGETED NANOVECTORS AND THEIR USE FOR TREATMENT OF BRAIN TUMORS
摘要
In some embodiments, the invention pertains to therapeutic compositions for treating a brain tumor. Such therapeutic compositions generally comprise: (1) a nanovector; (2) an active agent associated with the nanovector with activity against brain tumor cells; and (3) a targeting agent associated with the nanovector with recognition activity for a marker of the brain tumor cells. In some embodiments, the active agent and the targeting agent are non-covalently associated with the nanovector. Additional embodiments of the present invention pertain to methods of treating a brain tumor in a subject (e.g., a human being) by administering the aforementioned therapeutic compositions to the subject. Further embodiments of the present disclosure pertain to methods of formulating therapeutic compositions for treating a brain tumor in a subject in a personalized manner.
申请公布号
WO2013052158(A3)
申请公布日期
2014.05.01
申请号
WO2012US35267
申请日期
2012.04.26
申请人
WILLIAM MARSH RICE UNIVERSITY;TOUR, JAMES, M.;BERLIN, JACOB;MARCANO, DANIELA;BASKIN, DAVID, S.;SHARPE, MARTYN, A.;THE METHODIST HOSPITAL RESEARCH INSTITUTE
发明人
TOUR, JAMES, M.;BERLIN, JACOB;MARCANO, DANIELA;BASKIN, DAVID, S.;SHARPE, MARTYN, A.