IN VIVO IMAGING OF ENZYMATIC ACTIVITY

摘要

Compositions and methods are described for detecting enzyme activity in a live organism (e.g., animal) are provided. In a first embodiment, a composition is disclosed including a chemiluminescent enzymatic probe and a near-infrared (NR) nanoparticle. In additional embodiments, the composition may further include luminol and targeting moieties which may include an antibody, small molecule, an apatmer, or a polypeptide.