New process for the synthesis of 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile, and application in the synthesis of ivabradine and additional salts thereof with a pharmaceutically acceptable acid

摘要

NEW PROCESS FOR THE SYNTHESIS OF 3-(2-BROMO-4,5 DIMETHOXYPHENYL)PROPANENITRILE, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID Abstract A process for the synthesis of the compound of formula (I) is disclosed: (I) MeO Br Application of the compound of formula (I) in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof is also disclosed. MeO