IGF-II/IGF-IIE BINDING PROTEINS

摘要

PROBLEM TO BE SOLVED: To provide IGF-II/IGF-IIE binding proteins.SOLUTION: Proteins that bind to IGF-II and/or IGF-IIE, and a method of using such proteins, are disclosed. A novel method for treating a cancer is also disclosed. A cancer is treated by IGF-II/IGF-IIE binding proteins and additional therapy that is for example administering a growth hormone/growth hormone-releasing hormone pathway modulator, or inhibitor of an epidermal growth factor receptor or the like. In one aspect, this disclosure is characterized in proteins (for example, isolated proteins) that bind to IGF-II and IGF-IIE (for example, human IGF-II and IGF-IIE) and that include at least one immunoglobulin variable domain.