Lyophilized methionine-containing protein preparations stabilized over long time

摘要

A stable G-CSF formulation having a residual ratio of G-CSF of 90% or more after long-term storage testing at 25 DEG C for 3 months or a residual ratio of G-CSF of 90% or more after long-term storage testing at 40 DEG C for 2 months or a residual ratio of G-CSF of 90% or more after accelerated testing at 50 DEG C for 1 month or a residual ratio of G-CSF of 90% or more after accelerated testing at 60 DEG C for 2 weeks and a content of Met-oxidized G-CSF of 1% or less after accelerated testing at 50 DEG C for 1 month or after accelerated testing at 60 DEG C for 2 weeks.