发明名称 |
Hydrolytisch stabile stationäre lonenaustauschphasen und ihre Verwendungen |
摘要 |
<p>The invention provides novel ion-exchange media and related methods for their preparation and use. Ion-exchange stationary phases according to the invention are suitable for chromatographic separation of a variety of biomolecules. Distinguishing characteristics of ion-exchange media according to this invention includes, for example, their ability to separate variants of monoclonal antibodies via cation-exchange liquid chromatography using porous substrates with particle sizes <5μm. The ion-exchange stationary media include a hydrolytically stable layer, which inhibits surface degradation of the particles in 100% aqueous media. Another unique feature is low molecular weight building blocks used to functionalize the particles with ion-exchange groups.</p> |
申请公布号 |
DE102013014242(A8) |
申请公布日期 |
2014.04.30 |
申请号 |
DE20131014242 |
申请日期 |
2013.08.27 |
申请人 |
AGILENT TECHNOLOGIES, INC. |
发明人 |
BORDUNOV, ANDREI |
分类号 |
B01J41/20;B01D15/36;B01J47/00 |
主分类号 |
B01J41/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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