发明名称 |
TREATMENT OF PROTEINOPATHIES |
摘要 |
<p>The present disclosure provides technologies relating to lysosomal activation. The disclosure provides several strategies for increasing level and/or activity of lysosomal enzyme, and furthermore demonstrates the surprising applicability of such strategies in the treatment and/or prophylaxis of certain proteinopathies. Among other things, the present invention provides methods and compositions for the treatment and/or prophylaxis of proteinopathies other than lysosomal storage diseases through lysosomal activation. In particular, the present disclosure provides methods and compositions for the treatment and/or prophylaxis of neurodegenerative proteinopathies, and in particular those associated with accumulation ofα-synuclein. The present disclosure specifically provides methods and compositions for the treatment and/or prophylaxis of Parkinson's disease.</p> |
申请公布号 |
EP2723384(A1) |
申请公布日期 |
2014.04.30 |
申请号 |
EP20120802206 |
申请日期 |
2012.06.22 |
申请人 |
THE GENERAL HOSPITAL CORPORATION |
发明人 |
KRAINC, DMITRI;MAZZULLI, JOSEPH, R. |
分类号 |
A61K47/00;A61P25/28;G01N33/573 |
主分类号 |
A61K47/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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