Salts of 2-fluoro-n-methyl-4-[7-(quinolin-6-yl-methyl)- imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same

摘要

ABSTRACT - 602791 The disclosure relates to a process of preparing a compound of Formula (I) or salt thereof: comprising reacting a compound of Formula (II) with a compound of Formula (III) to form a compound of Formula (I), or salt thereof; wherein the process further comprises preparing the compound of Formula (II) by a process comprising reacting a compound of Formula (IIa) with a compound of Formula (IIb) for a length of time sufficient to generate a compound of Formula (II), wherein X1 is chloro, bromo, or iodo; and wherein the reacting of the compound of Formula (IIa) with the compound of Formula (IIb) is carried out in the presence of proline.