发明名称 |
NKp46-MEDIATED NK CELL TUNING |
摘要 |
The present invention relates to compounds (e.g. antibodies) that specifically bind and inhibit NKp46. Such compounds are capable, when administered to a mammal, capable of increasing the frequency of reactive and/or active NK cells. The invention also relates to pharmaceutical composition and methods of using the antibodies and compositions to treat or prevent diseases, e.g. cancer, infection, autoimmune diseases, inflammatory diseases and the like. |
申请公布号 |
EP2723362(A1) |
申请公布日期 |
2014.04.30 |
申请号 |
EP20120729116 |
申请日期 |
2012.06.21 |
申请人 |
INNATE PHARMA;INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE);UNIVERSITE DE LA MEDITERRANEE - AIX-MARSEILLE II;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) |
发明人 |
NARNI-MANCINELLI, EMILIE;UGOLINI, SOPHIE;VIVIER, ERIC |
分类号 |
A61K38/17;A61K39/00 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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