The present invention relates to pyrrolopyrazines compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.
申请公布号
EP2723746(A1)
申请公布日期
2014.04.30
申请号
EP20120730138
申请日期
2012.06.22
申请人
VERTEX PHARMACEUTICALS INC.
发明人
STORCK, PIERRE-HENRI;CHARRIER, JEAN-DAMIEN;RUTHERFORD, ALISTAIR;MORTIMORE, MICHAEL, PAUL;MACCORMICK, SOMHAIRLE;KNEGTEL, RONALD;DURRANT, STEVEN, JOHN