| 摘要 |
<p>NZ 594935 The disclosure relates to water–insoluble, matrix tablets capable of releasing one or more active ingredients into the body over an extended time period containing one active ingredient selected from morphine, oxycodone, hydrocodone, hydromorphone, oxymorphone, tramadol, methadone, codeine, fentanyl, buprenorphine and their salts which may be the subject of drug abuse dispersed within a compression matrix, wherein said compression matrix represents 50 to 98 weight % of the total weight of said tablet and contains at least one excipient chosen among microcrystalline cellulose, [polyvinyl acetate/polyvinylpyrrolidone (80:20)] and their mixtures, and a viscosity-increasing agent, leading to formation of a gel when the tablet is dissolved in a minimum amount of water.</p> |
