| 摘要 |
ABSTRACT - 600773 Disclosed herein is a carrier composition for delivery of a biologically active compound comprising a phosphate compound of an electron transfer agent and a polar protic solvent selected from the group consisting of acyclic alcohols, alkyl esters, ketones and nitriles, wherein the polar protic solvent concentration is within the range of 60%w/w to 90%w/w of the total concentration of the carrier composition. Wherein the acyclic alcohol may be selected from the group consisting of C1-C4 acyclic alcohols, polyols of C1-C4 acyclic alcohols, polymers of C1-C4 acyclic alcohols, and ester, alkyl ester, ether derivatives thereof, preferably ethanol, n-propanol, isopropanol, ethylene glycol, propylene glycol, polyethylene glycol, diethylene glycol monoethylether or ethyl acetate; the ketone is methyl isobutyl ketone or acetone; and the nitrile is acetonitrile, and the electron transfer agent may be a hydroxyl chroman, preferably a tocopherol or a tocotrienol, and the phosphate compound of tocopherol may be selected from the group consisting of mono-(tocopheryl) phosphate, mono-(tocopheryl) phosphate monosodium salt, mono-(tocopheryl) phosphate monopotassium salt, mono-(tocopheryl) phosphate disodium salt, mono-(tocopheryl) phosphate di-potassium salt, di-(tocopheryl) phosphate, di(tocopheryl) phosphate monosodium salt, di-(tocopheryl) phosphate monopotassium salt, or a mixture thereof. |
