发明名称 |
System for controlled release of an active principle and method for preparation |
摘要 |
A system for controlled release of an active principle, includes at least (a) a degradable polymer matrix which produces acid compounds and (b) at least one acid-sensitive complex of an active principle having at least one electrostatic charge and a complexing polyelectrolyte partner of opposite charge which complexes with the active principle. A method for preparation of such a system is described. The release of the active principle (7P) is prolonged over 18 days (ternary system PMLA/7P/PLAGA) in comparison to binary systems (7P/PLAGA) and (PMLA/7P). |
申请公布号 |
US8709481(B2) |
申请公布日期 |
2014.04.29 |
申请号 |
US20080669252 |
申请日期 |
2008.07.18 |
申请人 |
VERT MICHEL;LECLERCQ LAURENT;BOUSTTA MAHFOUD;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;UNIVERISTE DE MONTPELLIER 1 |
发明人 |
VERT MICHEL;LECLERCQ LAURENT;BOUSTTA MAHFOUD |
分类号 |
A61K9/14;A61K9/20;A61K47/48 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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