发明名称 6-O-substituted benzoxazole and benzothiazole compounds and methods of inhibiting CSF-1R signaling
摘要 Benzoxazole and benzothiazole compounds and the stereoisomers, tautomers, solvates, oxides, esters, and prodrugs thereof and pharmaceutically acceptable salts thereof are disclosed. Compositions of the compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier, and uses of the compounds, either alone or in combination with at least one additional therapeutic agent are also disclosed. The embodiments are useful for inhibiting cellular proliferation, inhibiting the growth and/or metathesis of tumors, treating or preventing cancer, treating or preventing degenerating bone diseases such as rheumatoid arthritis, and/or inhibiting molecules such as CSF-1R.
申请公布号 US8710048(B2) 申请公布日期 2014.04.29
申请号 US201213453202 申请日期 2012.04.23
申请人 SUTTON JAMES C.;WIESMANN MARION;WANG WEIBO;LINDVALL MIKA;LAN JIONG;RAMURTHY SAVITHRI;SHARMA ANU;MIEULI ELIZABETH J.;KLIVANSKY LIANA M.;LENAHAN WILLIAM;KAUFMAN SUSAN;YANG HONG;NG SIMON C.;PFISTER KEITH B.;WAGMAN ALLAN S.;SUNG VICTORIA;SENDZIK MARTIN;NOVARTIS AG 发明人 SUTTON JAMES C.;WIESMANN MARION;WANG WEIBO;LINDVALL MIKA;LAN JIONG;RAMURTHY SAVITHRI;SHARMA ANU;MIEULI ELIZABETH J.;KLIVANSKY LIANA M.;LENAHAN WILLIAM;KAUFMAN SUSAN;YANG HONG;NG SIMON C.;PFISTER KEITH B.;WAGMAN ALLAN S.;SUNG VICTORIA;SENDZIK MARTIN
分类号 A61K31/4439;A61K31/4545;A61K31/5377;A61K31/55;A61P9/10;A61P13/12;A61P19/10;A61P35/00;A61P35/02;C07D413/12;C07D413/14;C07D417/14 主分类号 A61K31/4439
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