发明名称 Heterocyclic compounds as CCR2B antagonists
摘要 Compounds of formula (I) Q-L-W—C(═X)—Z—P wherein Q is an amine of the formula—N(R1)(R2); L is an alkyl or heterocyclyl-alkyl linker; W is a 6- or 7-membered aliphatic ring comprising ring atoms Y1 and Y2 which are linked to groups L and C(X) respectively and Y1 and Y2 are independently selected from N and C; X is O, N, N—CN or S; Z is NR3; P is an optionally substituted monocyclic or bicyclic aryl or heteroaryl group; and pharmaceutically acceptable salts or solvates thereof, are useful in the treatment of C—C chemokine mediated conditions.
申请公布号 US8710224(B2) 申请公布日期 2014.04.29
申请号 US201314025939 申请日期 2013.09.13
申请人 ASTRAZENECA AB 发明人 BOWER JUSTIN FAIRFIELD;POYSER JEFFREY PHILIP;TURNER PAUL;WATERSON DAVID;WINTER JON JAMES GORDON
分类号 C07D241/02;A61K31/495 主分类号 C07D241/02
代理机构 代理人
主权项
地址