发明名称 |
Dihydronaphthyridinyl(organo)methanone analogs as positive allosteric mGluR5 modulators |
摘要 |
In one aspect, the invention relates to dihydronaphthyridinyl(organo)methanone analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
申请公布号 |
US8710074(B2) |
申请公布日期 |
2014.04.29 |
申请号 |
US201213349476 |
申请日期 |
2012.01.12 |
申请人 |
CONN P. JEFFREY;LINDSLEY CRAIG W.;STAUFFER SHAUN R.;MANKA JASON;JACOBS JON;ZHOU YA;BARTOLOMÉ-NEBREDA JOSÉ MANUEL;MACDONALD GREGOR JAMES;CONDE-CEIDE SUSANA;DAWSON ERIC S.;VANDERBILT UNIVERSITY |
发明人 |
CONN P. JEFFREY;LINDSLEY CRAIG W.;STAUFFER SHAUN R.;MANKA JASON;JACOBS JON;ZHOU YA;BARTOLOMÉ-NEBREDA JOSÉ MANUEL;MACDONALD GREGOR JAMES;CONDE-CEIDE SUSANA;DAWSON ERIC S. |
分类号 |
A61K31/4375;A61P3/04;A61P3/10;A61P25/00;A61P25/06;A61P25/08;A61P25/18;A61P25/28;A61P29/00;A61P35/00;C07D471/04 |
主分类号 |
A61K31/4375 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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