发明名称 |
Anti-infective derivatives, method for the production thereof, pharmaceutical compositions containing same and uses of said derivatives in treatment |
摘要 |
The present invention relates to bi-substrate inhibitor molecules combining (i) a pyridine, pyridinium or dihydropyridine-type structure allied to active metabolites of isoniazide, or related structures, and (ii) a hydrophobic substituent. The invention also relates to the method for preparing said molecules, to the pharmaceutical compositions containing said molecules, and to the use thereof as inhibitors of enoyl reductase for the preparation of a drug, especially an anti-infective drug for the treatment of tuberculosis. |
申请公布号 |
US8710073(B2) |
申请公布日期 |
2014.04.29 |
申请号 |
US20090866645 |
申请日期 |
2009.02.06 |
申请人 |
BERNADOU JEAN;BERNARDES-GENISSON VANIA;DELAINE TAMARA;QUEMARD ANNAÏCK;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.);UNIVERSITE PAUL SABATIER TOULOUSE III |
发明人 |
BERNADOU JEAN;BERNARDES-GENISSON VANIA;DELAINE TAMARA;QUEMARD ANNAÏCK |
分类号 |
A61K31/438;A61K31/455;A61P31/00;A61P31/04;A61P31/06;A61P31/08;A61P33/06;C07D211/90;C07D471/04 |
主分类号 |
A61K31/438 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|