发明名称 |
MODULATION OF STRUCTURED POLYPEPTIDE SPECIFICITY |
摘要 |
<p>The invention describes a method for selecting a polypeptide ligand having a desired level of specificity for a target, wherein the polypeptide ligand comprises a polypeptide comprising at least three reactive groups, separated by at least two loop sequences, and a molecular scaffold which forms covalent bonds with the reactive groups of the polypeptide such that at least two polypeptide loops are formed on the molecular scaffold, comprising (i) screening at least two different sets of polypeptide ligands against the target, and selecting one or more ligands from each library which interact with the target; (ii) comparing the activity of the selected ligands with one or more paralogues or orthologues of the target; and (iii) further selecting one or more ligands according to their activity towards said one or more paralogues or orthologues; wherein said two or more different sets of ligands differ in the length of the polypeptide loops formed on the molecular scaffold.</p> |
申请公布号 |
SG11201400888T(A) |
申请公布日期 |
2014.04.28 |
申请号 |
SGT11201400888 |
申请日期 |
2012.10.08 |
申请人 |
BICYCLE THERAPEUTICS LIMITED |
发明人 |
TITE, JOHN;WALKER, EDWARD;STACE, CATHERINE;TEUFEL, DANIEL |
分类号 |
C40B40/02;C07K1/107 |
主分类号 |
C40B40/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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