| 摘要 |
The invention provides the identification of the presence of polypeptides with ALK kinase activity in human cancer, such as ovarian cancer. In some embodiments, the polypeptide with ALK kinase activity is the result of a fusion between an ALK-encoding polynucleotide and an FNI-encoding polynucleotide. Six different fusion polypeptides are described, three that include the transmembrane and kinase domains ofALK fused to the extracellular domain of the FNI protein, and three that include the kinase domain (but not the transmembrane domain) ofALK fused to the extracellular domain of the FNI protein. |
