MGLU RECEPTOR ANTAGONIST FOR TREATING DISORDER ASSOCIATED WITH MGLU RECEPTOR INCLUDING ADDICTION AND DEPRESSION

摘要

PROBLEM TO BE SOLVED: To provide methods for treating disorders associated with metabotropic glutamate receptors (mGluRs) by simultaneously inhibiting at least two mGluRs belonging to at least two different groups.SOLUTION: There are provided methods for treating disorders associated with mGlu receptors 2, 3, and 5, such as nicotine addiction, cocaine addiction, and depression, the method including administering to a subject in need thereof an effective amount of at least one antagonist which modulates mGluR2, mGluR3, and mGluR5.